Improved nutrition for extremely low birth weight preemies
At the neonatology ward of the Vienna General Hospital (Medical University Vienna), physicians compared two mixtures of intravenous lipids for nutrition with support coming from the FWF. The researchers found no amelioration with respect to bile-flow complications in extremely low birth weight preterm babies in incubators, but they did discover more mature brain waves.
(firmenpresse) - In neonatology, complications are a daily occurrence. When babies are born long before term, their organs are not fully developed, rendering their health and bodily functions fragile. Respiratory insufficiency, brain haemorrhage, liver and intestinal problems as well as bacterial infections are some of the typical medical issues involved. In neonatology, medical staff need to be very alert, with iron nerves and great sensitivity. Despite the problems, preemies born as of the 23rd week of pregnancy usually survive the difficult weeks in the incubator without permanent damage. At the Division of Neonatology at Vienna less than one kilogram. They compared two approved lipid emulsions for intravenous feeding with respect to a typical complication relating to bile-flow from the liver (cholestasis) in premature babies.
Baby steps from emulsion to breast milk
Babies in an incubator need to be gradually introduced to breast milk. In order to supply the premature infants with vital lipids, protein, sugar and electrolytes, they are fitted not only with a gastric tube but also with intravenous access. Initially, most of their nutrition is administered intravenously. Andreas Repa therefore compared the emulsion based on soybean oil which has been used for many years with a preparation consisting of soybean oil, coconut oil, olive oil and fish oil. They wanted to find out whether this new preparation would have a positive impact on the incidence rate of cholestasis.
Study without additional blood sampling
preterm babies with a birth weight of less than one kilogram be part of the study: 100 babies received the soybean oil preparation, and 100 babies the mixed-oil emulsion, whereby neither the medical staff nor the parents knew who received what. Negative effects were precluded, since both preparations are approved for preterm babies. Whilst the composition was changed, the total amount of lipids administered intravenously remained constant in an attempt to reveal any unknown positive additional effects.
Significant effects in the brain, not the liver
The alternative nutrition showed no significant improvements as regards bile-flow complications. The EEGs, however, furnished a surprise result: al investigator.
Based on the experience of the neonatology experts, one out of four preterm babies develops cholestasis. follow-up study, Andreas Repa would like to take a closer look at any positive effects from the mix of fatty acids and is already looking for cooperation partners.
Personal details
Andreas Repa (https://www.meduniwien.ac.at/hp/programs-endocrinology/supervisors-topics/repa-andreas/) is a pediatrician specialising in neonatology at the Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Department of Pediatrics, Medical University of Vienna. In the context of the
Publications
Andreas Repa, Christoph Binder, Margarita Thanh/abstract), in: The Journal of Pediatrics 2017
A lipid emulsion containing fish oil and brain maturation in extremely low birth weight infants
Andreas Repa, Ruth Lochmann, Lukas Unterasinger, Michael Weber, Angelika Berger, Nadja Haiden: Aggressive nutrition in extremely low birth weight infants: impact on parenteral nutrition associated cholestasis and growth (https://peerj.com/articles/2483/), in: Peer J 2016
Andreas Repa, Margarita Thanhaeuser, David Endress, Michael Weber, Alexandra Kreissl, Christoph Binder, Angelika Berger, Nadja Haiden: Probiotics (Lactobacillus acidophilus and Bifidobacterium infantis) prevent NEC in VLBW infants fed breast milk but not formula (https://www.nature.com/articles/pr2014192), in: Pediatric Research 2015
Image and text will be available as of Wednesday, 27th December 2017, from 9.00 am CET at: http://scilog.fwf.ac.at/en
Scientific Contact
Ass.-Prof. Andreas Repa, PhD
Medical University Vienna
Department of Pediatrics
W
1090 Vienna, Austria
T +43 / 1 / 40400-32320
E andreas.repa(at)meduniwien.ac.at
W https://www.meduniwien.ac.at/web/
Austrian Science Fund FWF
Ingrid Ladner
Haus der Forschung
Sensengasse 1
1090 Vienna, Austria
T +43 / 1 / 505 67 40 - 8117
E ingrid.ladner(at)fwf.ac.at
W http://scilog.fwf.ac.at/en/
W http://www.fwf.ac.at/en
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Datum: 08.01.2018 - 04:04 Uhr
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News-ID 1531069
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Date of sending: 08.01.2018
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