The New VITROCELL® Cloud Alpha MAX

Smallest nebulization volumes and high deposition efficiency

ID: 1564034
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(PresseBox) - The VITROCELLand 24-well). It?s functionality enables fully automated processes with an all-in-one control unit. Everyday experiments at the air/liquid interface have never been easier.

The new Cloud Alpha MAX?series was developed as a result of numerous customer requests and is now capable to expose mammalian cell cultures in 6-, 12- or 24-well sized cell culture inserts. All commercial brands are supported.

The Cloud system is suitable for nebulization of solutions and

Exposure at the Air?/?Liquid Interface

In response to the scientific need to expose in physiologically relevant conditions, the VITROCELLstances with the culture media.

Cell systems cultivated on membrane inserts are exposed at the Air/Liquid Interface (ALI) so that the test substances are received directly. This approach allows for more credible and authentic results than by submerged exposure due to a closer replication of the human physiology.

Smallest nebulization volumes ? high deposition efficiency


This is important when only small quantities of material are available or when expensive test substances need to be tested. The non-cell exposed area is reduced significantly by direct nebulization into exposure chambers with reduced chamber volume. Different chamber volumes are available.

A set of 3 nebulizers allows for simultaneous testing of 3 concentrations, or a combination of Microbalance for dosimetry, control liquid and suspension of the test substance.

Choice of three types of nebulizers

The system comes with a choice of 3 types of vibrating mesh nebulizers having droplet MMAD ranges of 2.5 ? 6.0

Recommended nebulisation volumes are 30???40

Dosimetry using Quartz Crystal Microbalance (QCM)

The QCM sensor is integrated in the Cloud Alpha MAX exposure module. It is capable of measuring the deposited mass at a resolution of 10 nanogram/cm2 per second. Results are reported online by the VITROCELL

Key Features:

Lowest nebulization volumes: ? 40

High deposition efficiency

Cloud dynamics by vibrating mesh nebulizers

Easy handling with no external air-flow required

High reproducibility

Air Liquid Interface (ALI) exposure

Direct and efficient guidance of substance exposure to the cells

80, 40, 10 mm tube length


Graph 1: Air?/?Liquid Cultivation and Exposure in Exposure Module.

Photo 2: Different chamber volumes are available.

Photo 3: The system comes with a choice of 3 types of vibrating mesh nebulizers.

Photo 4: The QCM sensor (right position) is integrated in the Cloud

Advanced in vitro exposure systems

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Advanced in vitro exposure systems

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Date: 01/22/2021 - 08:43
Language: English
News-ID 1564034
Character count: 4218
Firma: VITROCELL Systems GmbH
Ansprechpartner: Feedback to about Pressrelease-id:
Stadt: Waldkirch


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