​New Study Links Stress to Weight Gain
A new study confirms that constant stress can prevent weight lose, and it seems to be a protein to blame.
(firmenpresse) - A new study confirms that constant stress can prevent weight lose, and it seems to be a protein to blame. In cell and mouse model experiments, University of Florida Health researchers have discovered that chronic stress stimulates production of betatrophin, a protein that inhibits an enzyme involved in fat metabolism. These recent findings were published this month in the journal BBA Molecular and Cell Biology of Lipids.
Betatrophin''s role as a stress-related protein brings new attention. It was once recognized by researchers as a breakthrough therapy for diabetes, but later deemed ineffective.
While the latest properties of betatrophin have yet to be tested in a clinical setting, one researcher said the findings have potential implications for humans.
€œBetatrophin reduces the body''s ability to break down fat, underscoring a link between chronic stress and weight gain," said Li-Jun Yang, M.D., a professor and lead investigator in the UF College of Medicine''s department of pathology, immunology and laboratory medicine. In the present study, mouse models experiencing metabolic stress produced significantly more betatrophin, and their normal fat-burning processes slowed down tremendously . €œSuch observations are significant because they shed new light on the biological mechanisms linking stress, betatrophin and fat metabolism" Yang said. The results provide experimental evidence that stress makes it harder to break down body fat, according to Yang and co-first author Yuan Zhang, M.D., who is completing her Ph.D. They also discovered why more betatrophin leads to less fat burning: It suppresses adipose triglyceride lipase, an enzyme that breaks down stored fat.
Experiments on cells derived from mice and humans were first used to establish betatrophin''s role in body fat regulation, Yang said. Next, researchers studied how betatrophin levels increased as mouse models experienced environmental and metabolic stress. Both types of stress boosted betatrophin production in fat tissue and the liver. That finding established betatrophin is a stress-related protein, Yang said.
Researchers have yet to test betatrophin''s effect on fat metabolism in humans, the new findings confirm that reducing stress can be beneficial to weight loss. While short-term mild stress can help people perform better and get through difficult situations, long-term stress can be far more detrimental.
€œStress causes you to accumulate more fat, or at least slows down fat metabolism. This is yet another reason why it''s best to resolve stressful situations and to pursue a balanced life," Yang said.
http://www.nextgennutritionals.com/article/fatmetabolism
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Datum: 02.02.2016 - 23:19 Uhr
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News-ID 1412844
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type of sending: Veröffentlichung
Date of sending: 02/02/2016
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