AFFiRiS AG: ALZHEIMER'S VACCINE AD02 ALREADY IN CLINICAL PHASE II
Vienna (Austria), 23. April 2010: AFFiRiS AG's clinical Alzheimer's vaccine candidate AD02
has already progressed to phase II clinical testing. It may therefore be possible to confirm the
efficacy of the vaccine as early as during 2012. Indeed the start of this efficacy study comes
only five months after the completion of the corresponding phase I study. The company is
active in several disease areas and is currently developing a total of twelve prospective
products in all stages of the development pipeline up to clinical phase II.
(firmenpresse) -
Vienna (Austria), 23. April 2010: AFFiRiS AG's clinical Alzheimer's vaccine candidate AD02
has already progressed to phase II clinical testing. It may therefore be possible to confirm
the efficacy of the vaccine as early as during 2012. Indeed the start of this efficacy study
comes only five months after the completion of the corresponding phase I study. The
company is active in several disease areas and is currently developing a total of twelve
prospective products in all stages of the development pipeline up to clinical phase II.
The prospective Alzheimer's vaccine AD02 by AFFiRiS AG will with immediate effect be
used in a multicentre phase II clinical study in Austria and five other European countries.
Clinical centres in Germany, France, the Czech Republic, Slovakia and Croatia are taking
part in the study. A total of 420 patients will be recruited. Interested parties can find further
information about the study on the homepage www.affiris.com. There is also a link to study
registration via a trustee. You can also phone +43 512 56 73 73-0 (reference
"Alzheimerstudie") please ask Ms Weiss.
During the past year the safety and tolerability of the vaccine has been confirmed; now the
focus is on its efficacy. With regard to this, CEO and co-founder of the company Dr. Walter
Schmidt said: "Last year AD02, along with our second prospective Alzheimer's vaccine
AD01, was primarily tested in terms of its safety and tolerability. Those primary endpoints
have been met by vaccine formulations. The decision to nominate AD02 for phase II
testing study is based on currently still confidential results of the interim analysis of the
secondary endpoints of the preceding phase I studies".
ATTRACTIVE PRODUCT PIPELINE - CLEAR PRIORITIES
The other reason for deciding to accelerate the progress of AD02 is the company's
principle to set clear priorities in respect of its broad product pipeline. The pipeline also
comprises vaccines for treating atherosclerosis, hypertension and three other indications,
which are currently still confidential. In addition, AFFiRiS AG announced only a few weeks
ago that a prospective vaccine for the treatment of Parkinson's disease will start phase I
clinical studies at the beginning of 2011.
With regard to the extent of the development pipeline CSO Dr. Frank Mattner stated:
"Even before the start of the company's first phase II study we were able to build up a very
broad product pipeline. This success is based on two components: our AFFITOME®
technology and our solid financial basis. The AFFITOME® technology is increasingly
proving itself to be more than an ideal platform technology for our product developments. It
provides innovative solutions for the therapeutic treatment of chronic diseases with unmet
medical need and opens up attractive markets for us. Our investors, the MIG Fonds, had
already recognised this potential four years ago. In this way they assured us of early and
substantial financing, which has contributed decisively to the rapid and successful progress
of our development projects".
STRATEGY WITH SUCCESS
The first successes of this business strategy came in October 2008 when GlaxoSmithKline
(GSK) Biologicals acquired the licence to the rights to the Alzheimer's vaccines in a
milestone deal with a value of up to EUR 430 million. Two payments totalling EUR 32.5
million have already been triggered. AFFiRiS AG continues to hold all rights on the
AFFITOME® technology for other indications. In summary, the AFFITOME® technology
delivers short peptides which functionally mimic highly-specific original native structures that
are the key targets for treatment of chronic diseases. Based on these peptides, vaccines
can be generated which induce antibodies targeting pathological variants of human
proteins, but leaving parental "healthy" structures untouched.
Themen in dieser Pressemitteilung:
Unternehmensinformation / Kurzprofil:
About AFFiRiS AG (date April 2010):
On the basis of the company's own patents, AFFiRiS develops tailor-made peptide vaccines
against Alzheimer's disease, atherosclerosis, Parkinson's disease hypertension and four other
conditions with an urgent medical requirement and attractive market volumes. Alzheimer's is
currently the most advanced project, with two potential products having just completed the
phase I clinical studies. In October 2008 GlaxoSmithKline Biologicals became the licence
partner for the Alzheimer's vaccine. The contract envisages (milestone-dependent) payments
of up to EUR 430 million. A payment of EUR 10 million was triggered in October 2009 by the
positive completion of two clinical phase I studies. At present AFFiRiS has 70 highly qualified
employees working at the St. Marx campus in Vienna, Austria (www.affiris.com).
Contact AFFiRiS AG:
Mag. Agnes Meyer
Karl-Farkas-Gasse 22
1030 Vienna
T +43 / 1 / 798 15 75 - 390
E agnes.meyer(at)affiris.com
W www.affiris.com
Copy Editing & Distribution:
PR&D - Public Relations for Research & Education
Campus Vienna Biocenter 2
1030 Vienna
T +43 / 1 / 505 70 44
E contact(at)prd.at
W www.prd.at
Datum: 23.04.2010 - 05:29 Uhr
Sprache: Deutsch
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